For treatment of flagellates & hole-in-head disease. Effective in treating many species of flagellates such as Spironucleus and Hexamita. Hole-in-head disease is not caused by flagellates, but instead is primarily the result of insufficient water hygiene and one-sided nutrition as well as a diet that is low in vitamins and minerals. Amount required: 500L of tank water. Dosage: 10 ml / 50L of water; in case of repeated treatment 100 ml are enough for a 250L tank.